Lupus & antiphospholipid syndrome
Serological clusters in systemic lupus erythematosus and its clinical and prognostic implications: A longitudinal cohort study
Authors' conclusion
In our SLE patient population, the serological profile is key not only for clinical stratification but also for prognostic value.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients from the Spanish Registry RELESSER718 in prospective phase
- Participants
- 1,740 patients
- Exposure
- Four serological clusters of SLE patients
- Outcome
- Clinical characteristics of serological clusters
Methodological detailsdescriptive, observational, multicentre, cluster analysis (Gower distance)
- Descriptive
- Observational
- Multicentre
- Cluster analysis (Gower distance)
Main finding
As reported in the abstract
- Four serological clusters identified
- Four
Observational data: associations, not effects.
Further findings
Damage and severity · baseline, persisting over 4-year follow-up
- Cluster 2 had higher baseline damage scores (SLICC/ACR DI)
- Cluster 4 had higher severity scores (Katz Index)
- Differences among clusters persisted over the four-year follow-up
Original publication
Serological clusters in systemic lupus erythematosus and its clinical and prognostic implications: A longitudinal cohort study. Semin Arthritis Rheum. Published 28 August 2025. doi:10.
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