Lupus & antiphospholipid syndrome
Ultrasensitive serum interleukin-8 levels show no association with disease activity or autoantibody profile but relate to cardiovascular comorbidity in systemic lupus erythematosus
Authors' conclusion
In SLE, IL-8 is not associated with disease activity or autoantibody profile but may contribute mechanistically to dyslipidaemia and accelerated atherosclerosis.
Study context
- Population
- Patients with SLE; serum IL-8 measured by ultrasensitive Single Molecule Array (Simoa®)
- Participants
- 235 patients
- Outcome
- Associations of serum IL-8 levels with disease activity, serological and cardiovascular features
Methodological detailsobservational, multivariable linear regression
- Observational
- Multivariable linear regression
Main finding
As reported in the abstract
Serum IL-8 associations
- Disease activity scores, damage indices and autoantibody profiles: no significant association with IL-8
- IL-8 inversely associated with total and non-HDL cholesterol (adjusted models)
- SCORE2 cardiovascular risk score: significant positive association with IL-8
Observational data: associations, not effects.
Original publication
Ultrasensitive serum interleukin-8 levels show no association with disease activity or autoantibody profile but relate to cardiovascular comorbidity in systemic lupus erythematosus. Clin Exp Rheumatol. Published 28 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →