Lupus & antiphospholipid syndrome
SLE inflammatory musculoskeletal abnormalities, confirmed by MRI, show a specific profile with a worse health-related quality of life
Authors' conclusion
SLE patients with confirmed musculoskeletal alterations on MRI were generally older, less likely to have lupus nephritis, and received different treatments. They reported a worse HRQoL in terms of pain, fatigue and functional disability.
Study context
- Population
- Patients with SLE from a previous study who had a contrast wrist and hand MRIanalysed
- Participants
- 83 patients
- Exposure
- SLE patients with vs without MRI-confirmed inflammatory musculoskeletal abnormalities (wrist and hand)
- Outcome
- Clinicodemographic or serological profile associated with MRI-confirmed inflammatory musculoskeletal abnormalities; relationship with HRQoL
Main finding
As reported in the abstract
Profile associated with MRI abnormalities
- Age, erosions vs none (years): 55 ± 12.61 vs 45.06 ± 12.18
- p .001
- Age, synovitis vs none (years): 52.78 ± 12.99 vs 44.95 ± 12.49
- p .011
- Nephritis, synovitis vs none: 6.7% vs 24.3% (less frequent)
- p .031
- Methotrexate, bone edema vs none: 25% vs 6.3%
- p .033
- Mycophenolic acid, erosions vs none: 5.6% vs 22.9%
- p .034
- Mycophenolic acid, peritendonitis vs none: 0% vs 12.8%
- p .026
- SLEDAI-2K, peritendonitis vs none: 7 ± 2.45 vs 3.64 ± 3.34
- p .018
Observational data: associations, not effects.
Further findings
HRQoL by MRI abnormality
- Pain, synovitis vs none: 6.03 ± 2.57 vs 4.26 ± 2.49
- p .005
- Pain, tenosynovitis vs none: 6.56 ± 1.95 vs 4.76 ± 2.75
- p .017
- Pain, peritendonitis vs none: 8.80 ± 1.30 vs 4.95 ± 2.55
- p .001
- Pain, bone edema vs none: 6.47 ± 2.62 vs 4.83 ± 2.58
- p .026
- Fatigue NRS, synovitis vs none: 2.32 ± 0.82 vs 1.91 ± 0.84
- p .035
- FSS-9, tenosynovitis vs none: 61.50 ± 1.73 vs 45.70 ± 16.80
- p .015
- HAQ, synovitis vs none: 1.14 ± 0.69 vs 0.75 ± 0.65
- p .031
- HAQ, peritendonitis vs none: 1.69 ± 0.07 vs 0.90 ± 0.69
- p .018
Original publication
SLE inflammatory musculoskeletal abnormalities, confirmed by MRI, show a specific profile with a worse health-related quality of life. Lupus. Published 20 November 2024. doi:10.
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