Lupus & antiphospholipid syndrome
Musculoskeletal involvement in systemic lupus erythematosus: a contrast-enhanced magnetic resonance imaging study in 107 subjects
Authors' conclusion
SLE patients have a high prevalence of inflammatory musculoskeletal alterations confirmed by contrasted MRI, even if asymptomatic.
Study context
- Population
- SLE patients fulfilling SLICC criteria (Jaccoud arthropathy, CCPa and RF positivity, hand OA or surgery excluded) and healthy subjects; contrasted MRI of non-dominant hand/wrist
- Participants
- 107 patients
- Exposure
- SLE patients with hand/wrist arthritis, arthralgia or no symptoms vs healthy subjects
- G1n = 31
- G2n = 31
- G3n = 21
- G4n = 24reference
- Outcome
- Prevalence of joint and tendon involvement in hand and wrist on contrasted MRI (RAMRIS extended to PIP, RA tenosynovitis score, PsAMRIS peritendonitis)
Methodological detailscontrast-enhanced MRI, healthy controls
- Contrast-enhanced MRI
- Healthy controls
Main finding
As reported in the abstract
Any lesion
P 0.002
Observational data: associations, not effects.
Further findings
Synovitis — G1 vs G4 · across groups
P 0.013
Erosions — G1 vs G4 · across groups
P 0.066
Bone marrow oedema — G1 vs G4 · across groups
P 0.046
Tenosynovitis — G1 vs G4 · across groups
P 0.005
Peritendonitis — G1 vs G4 · across groups
P 0.07
Original publication
Musculoskeletal involvement in systemic lupus erythematosus: a contrast-enhanced magnetic resonance imaging study in 107 subjects. Rheumatology (Oxford). Published 19 May 2023. doi:10.
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