Lupus & antiphospholipid syndrome
Immunological disease activity parameters at conception are risk factors for preterm birth and low birth weight in patients with systemic lupus erythematosus
Authors' conclusion
PB and LBW are strongly associated with disease activity parameters in patients with SLE.
Study context
- Population
- Pregnancies in patients with systemic lupus erythematosus (SLE)
- Participants
- 60 pregnancies
- Outcome
- Preterm birth (PB) and low birth weight (LBW) in relation to disease activity parameters (SLE Disease Activity Index (SLEDAI), lupus low disease activity state (LLDAS) attainment, complement levels, anti-dsDNA titer)
- Follow-up
- At conception
Methodological detailslogistic regression
- Logistic regression
Main finding
As reported in the abstract
- C3 levels associated with preterm birth (PB)
- p = 0.03
- Anti-dsDNA antibody titers associated with PB
- p = 0.01
- C3 levels associated with low birth weight (LBW)
- p = 0.02
- CH50 levels associated with LBW
- p = 0.03
Observational data: associations, not effects.
Further findings
Cutoff values (logistic regression) for PB and LBW
- C3 cutoff for PB
- 62.0 mg/dl
- Anti-dsDNA antibody cutoff for PB
- 5.4 IU/ml
- C3 cutoff for LBW
- 87.0 mg/dl
- CH50 cutoff for LBW
- 41.8 U/ml
Combination of cutoff values: risk of PB and LBW
- Significantly higher risk of PB
- P = 0.01
- Significantly higher risk of LBW
- P < 0.01
Original publication
Immunological disease activity parameters at conception are risk factors for preterm birth and low birth weight in patients with systemic lupus erythematosus. Lupus. Published 16 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →