Lupus & antiphospholipid syndrome
Maternal and neonatal outcomes in SLE: comparison of 430 pregnancies from the French GR2 study with 1720 pregnancies from French perinatal surveys
Main finding · Live birthsResult — go to the resultOR for live birth 1.49 CI 0.64–3.45Authors' conclusion
Among pregnancies progressing beyond 22 WG (or birth weight ≥500 g), live birth rates were comparable to those in the general population, but APOs were more than two times as frequent in women with SLE.
Study context
- Population
- Pregnancies in women with SLE from the French GR2 cohort and pregnancies from the French general population (Enquêtes Nationales Périnatales (ENP)), resulting in a birth ≥22 weeks of gestation (WG) or ≥500 g430 GR2 pregnancies matched to 1720 ENP pregnancies
- Participants
- 430 vs 1,720
- Exposure
- Pregnancies from the prospective GR2 cohort vs those from the French general population using perinatal survey (ENP) data
- GR2 (SLE)n = 430
- ENPn = 1,720reference
- Outcome
- Live births
Methodological detailsperinatal survey data, each GR2 pregnancy matched with four ENP pregnancies based on maternal age, parity, number of fetuses and region, multivariate analysis
- Perinatal survey data
- Each GR2 pregnancy matched with four ENP pregnancies based on maternal age, parity, number of fetuses and region
- Multivariate analysis
Main finding
As reported in the abstract
OR for live birth
1.49
CI 0.64–3.45
P = 0.14
Events by group
GR2 (SLE)vs ENP
OR for live birth 1.49 (CI 0.64–3.45); P = 0.14
Observational data: associations, not effects.
Further findings
| Outcome | GR2 (SLE) | ENP | Estimate | P value | |
|---|---|---|---|---|---|
| Adverse pregnancy outcomes (APOs), among live births with complete medical records | 18.5% | 8.2% | OR 2.53 (CI 1.86–3.44) | P < 0.001 | |
| APOs, adjusted (multivariate analysis)SLE remained independently associated with APOs | aOR 2.91 (CI 2.06–4.09) | P < 0.001 | |||
| 0.20.5125Ratio (log scale) |
| Outcome | P value |
|---|---|
| APOs in GR2 pregnancies without disease activity, organ damage or LA positivity (subgroup) vs ENP pregnanciesHigher in GR2 subgroup | P < 0.01 |
- Adverse pregnancy outcomes (APOs) in GR2 pregnancies without disease activity, organ damage or lupus anticoagulant (LA) positivity (subgroup) vs ENP pregnancies: GR2 without disease activity, organ damage or LA positivity 14.4%
GR2 characteristics at inclusion
- No clinical lupus activity
- 336/397 (84.6%)
- No organ damage
- 327/385 (84.9%)
- LA-positive
- 68/428 (15.9%)
- Received hydroxychloroquine
- 417/430 (97.0%)
APO-associated factors (univariate analysis)
- SLE, nulliparity, smoking, chronic hypertension, twin pregnancy and fertility treatment identified as APO-associated factors
Original publication
Maternal and neonatal outcomes in SLE: comparison of 430 pregnancies from the French GR2 study with 1720 pregnancies from French perinatal surveys. Lupus Sci Med. Published 3 November 2026. doi:10.
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