Spondyloarthritis & psoriatic arthritis
NSAID exposure delays time-to-pregnancy in patients with spondyloarthritis: an analysis of the GR2 prospective cohort
Authors' conclusion
Age and NSAID use during preconception were significantly associated with a longer TTP, after adjustment for other confounding factors.
Study context
- Population
- Consecutive women with spondyloarthritis (SpA) (per their rheumatologist) wanting to become pregnant, France, 2015–2021included before conception
- Participants
- 88 women
- Outcome
- TTP (months), from study inclusion to conception
Methodological detailsobservational, multicentre (63 centres), Shared Frailty Cox models with random centre effect, multiple imputation
- Observational
- Multicentre (63 centres)
- Shared Frailty Cox models with random centre effect
- Multiple imputation
Main finding
As reported in the abstract
TTP
Women who became pregnant during follow-up
56
63.6%
Median time to pregnancy (TTP), months
16.1
95% CI 12.2 to 25.3
Observational data: associations, not effects.
Further findings
Factors associated with TTP (multivariate model)
- Age (per year), HR
- 1.22 (95% CI 1.08 to 1.40; p<0.001)
- NSAID use during preconception, HR
- 3.01 (95% CI 2.15 to 3.85; p=0.01)
Original publication
NSAID exposure delays time-to-pregnancy in patients with spondyloarthritis: an analysis of the GR2 prospective cohort. RMD Open. Published 29 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →