Lupus & antiphospholipid syndrome
Histone‐Specific CD4+ T Cell Plasticity in Active and Quiescent Systemic Lupus Erythematosus
Authors' conclusion
Histone-specific T cells are selectively detected in patients with SLE, and their concentration in the blood varies with disease activity
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) (autoantibody seroprevalence and HLA-DRB1 profile assessed), patients with TAK and healthy controls carrying HLA-DRB1*03:01 and/or HLA-DRB1*11:01patients with SLE
- Participants
- 185 patients
- Comparison
- Patients with SLE vs patients with Takayasu arteritis and healthy controls; active vs quiescent SLE
- Outcome
- Histone-specific CD4+ T cells
Methodological detailsflow cytometry, ex vivo detection of antigen-specific T cells, Disease activity and remission estimated with SLEDAI-2K and LLDAS
- Flow cytometry
- Ex vivo detection of antigen-specific T cells
- Disease activity and remission estimated with SLEDAI-2K and LLDAS
Main finding
As reported in the abstract
Patients with history of anti-DNA antibodies with detectable histone-specific T cells
77%
Patients with history of anti-DNA antibodies with lymphocytes releasing cytokines or upregulating activation markers after in vitro histone peptide challenge
50%
Further findings
Immunosuppressants and histone-specific T cell subsets
- Immunosuppressants associated with expanded CD4+ histone-specific naive and terminally differentiated T cells
Original publication
Histone‐Specific CD4+ T Cell Plasticity in Active and Quiescent Systemic Lupus Erythematosus. Arthritis Rheumatol. Published 7 February 2024. doi:10.
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