Lupus & antiphospholipid syndrome
Expression patterns of T cells-specific long noncoding RNAs in systemic lupus erythematosus patients carrying human leukocyte antigens (HLA) risk/nonrisk alleles
An erratum to this article was published (Lupus, Dec 2026 ↗)
Authors' conclusion
Our results indicate that the contribution of multiple T cell subsets in SLE disease progression as judged by expression analysis of LncRNAs and transcription factors can be inspired by the inheritance of HLA risk/nonrisk alleles is SLE patients.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients genotyped for HLA-DRB1 and HLA-DQB1 loci
- Participants
- 106 patients
- Exposure
- HLA risk allele-positive vs HLA risk allele-negative SLE patients
- HLA-RPosn = 47
- HLA-RNegn = 59reference
- Outcome
- Peripheral transcript levels of T-cell-specific Long noncoding RNAs (LncRNAs) (IFNG-AS1, RMRP, Th2LCR, DQ786243) and transcription factor mRNAs (Foxp3, Gata3, Tbx21)
Methodological detailsPCR-SSP genotyping, qRT-PCR
- PCR-SSP genotyping
- qRT-PCR
Main finding
As reported in the abstract
- Decreased DQ786243 transcript levels in HLA-RPos
- p = .001
- Elevated IFNG-AS1 expression in HLA-RPos
- p = .06
- Elevated T-bet mRNA in HLA-RPos
- p = .03
Observational data: associations, not effects.
Further findings
Expression, DR3-positive vs DR3-negative (subgroup)
- Significantly lower Th2LCR expression in DR3-positive
- P < 0.0001
- Significantly lower DQ786243 expression in DR3-positive
- P = 0.001
- Higher Tbx21 expression in DR3-positive
- P = 0.009
- Higher Foxp3 expression in DR3-positive
- P = 0.02
Expression, DR16-positive vs DR16-negative (subgroup)
- Decreased DQ786243 transcript levels in DR16-positive
- P = 0.02
- Decreased RMRP transcript levels in DR16-positive
- P = 0.003
ROC curve analysis
- Potential of DQ786243 and RMRP as biomarkers in SLE based on carriage of HLA risk alleles
Original publication
Expression patterns of T cells-specific long noncoding RNAs in systemic lupus erythematosus patients carrying HLA risk/nonrisk alleles. Lupus. Published 23 August 2023. doi:10.
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