Lupus & antiphospholipid syndrome
Clinical characteristics and prognosis in systemic lupus erythematosus-associated pulmonary arterial hypertension based on consensus clustering and risk prediction model
Authors' conclusion
Consensus clustering identified two distinct SLE-PAH subtypes which were associated with survival outcomes. Four prognostic factors for death were discovered to construct the SLE-PAH risk prediction model.
Study context
- Population
- Patients with Pulmonary Arterial Hypertension (PAH) (SLE-PAH and idiopathic PAH), First Affiliated Hospital of Zhengzhou University, July 2014 to June 2021163 SLE-PAH, 42 idiopathic PAH
- Participants
- 205 patients
- Exposure
- SLE-PAH cluster 2 vs cluster 1
- Cluster 2n = 29
- Cluster 1n = 134reference
- Outcome
- Survival rate
- Follow-up
- Within 2 years
Methodological detailssingle-centre, unsupervised consensus clustering, LASSO combined with Cox proportional hazards regression risk prediction model
- Single-centre
- Unsupervised consensus clustering
- LASSO combined with Cox proportional hazards regression risk prediction model
Main finding
As reported in the abstract
P < 0.05
Observational data: associations, not effects.
Further findings
SLE-PAH risk prediction model
- Model included older age at diagnosis (≥ 38 years), anti-dsDNA antibody, neuropsychiatric lupus and platelet distribution width (PDW)
Original publication
Clinical characteristics and prognosis in systemic lupus erythematosus-associated pulmonary arterial hypertension based on consensus clustering and risk prediction model. Arthritis Res Ther. Published 23 August 2023. doi:10.
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