Lupus & antiphospholipid syndrome
Prolonged serologically active clinically quiescent systemic lupus erythematosus: a longitudinal study on the role of IgG anti-dsDNA and C3
Authors' conclusion
Most SACQ patients developed clinical flares. Changes in IgG anti-dsDNA and C3 levels emerged as strong predictors of flare in prolonged SACQ patients in a visit-by-visit analysis
Study context
- Population
- Patients with prolonged serologically active clinically quiescent (SACQ) systemic lupus erythematosus (SLE) (≥6 months of elevated IgG anti-dsDNA and/or low C3 without clinical activity, BILAG-2004 D/E in all domains), University College London Hospital Lupus cohort, 2020–2025
- Participants
- 60 patients531 visits
- Outcome
- Flares and sustained activity predicted by fluctuations in IgG anti-dsDNA and C3 levels
Methodological detailsgeneralized estimating equations, adjusted for main confounders, single cohort (University College London Hospital Lupus cohort)
- Generalized estimating equations
- Adjusted for main confounders
- Single cohort (University College London Hospital Lupus cohort)
Main finding
As reported in the abstract
mean 3.3-year follow-up
≥1 flare
38 patients
63.3%
Observational data: associations, not effects.
Further findings
Baseline characteristics, patients with vs without flares
- Comparable, except longer follow-up duration among those who developed flares
- P = 0.005
- Higher prevalence of anti-Ro positivity among those who developed flares
- P = 0.018
Original publication
Prolonged serologically active clinically quiescent systemic lupus erythematosus: a longitudinal study on the role of IgG anti-dsDNA and C3. Rheumatology (Oxford). Published 29 July 2026. doi:10.
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