Lupus & antiphospholipid syndrome
Does remission in systemic lupus erythematosus according to the 2021 Definition Of Remission In SLE (DORIS) definition match the treating rheumatologist’s judgement?
Authors' conclusion
There is substantial agreement between the DORIS definition and physician-judged remission. The discordance was mainly due to physicians classifying some patients with ongoing mild disease activity as in remission.
Study context
- Population
- SLE patients from a Spanish prospective multicentre study (92% women; mean age 50.4 years)
- Participants
- 267 vs 277
- Exposure
- 2021 DORIS remission vs physician-judged remission
- 2021 DORISn = 267
- Physician judgementn = 277reference
- Outcome
- Agreement between 2021 DORIS remission and physician-judged remission
Methodological detailsdata from a Spanish prospective multicentre study
- Data from a Spanish prospective multicentre study
Main finding
As reported in the abstract
Overall rate of agreement
81.2%
95% CI 79.9–82.9%
2021 DORIS
Cohen's kappa
0.62
95% CI 0.55–0.69
2021 DORIS
Observational data: associations, not effects.
Further findings
Remission/serologically active clinically quiescent (SACQ) per rheumatologists but not meeting 2021 DORIS criteria, and reasons
- Discordant patients
- 46 (9.1%)
- Clinical SLE Disease Activity Index (cSLEDAI) score >0
- 39 patients
- PGA score >0.5
- five patients
- Prednisone >5 mg/day
- five patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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