Lupus & antiphospholipid syndrome
Does expert opinion match the definition of lupus low disease activity state? Prospective analysis of 500 patients from a Spanish multicentre cohort
Authors' conclusion
Almost two-thirds of SLE patients were in the LLDAS. There was a fair correlation between the LLDAS and the physician's evaluation. This agreement improves for patients fulfilling the LLDAS criteria.
Study context
- Population
- SLE patients from a Spanish multicentre prospective cohort (92% women; mean age 50.4 years)
- Participants
- 508 patients
- Exposure
- Lupus low disease activity state (LLDAS) definition vs physician's subjective evaluation of lupus activity
- Outcome
- Agreement between LLDAS and physician's subjective evaluation of lupus activity
Methodological detailscross-sectional analysis of a prospective study, multicentre
- Cross-sectional analysis of a prospective study
- Multicentre
Main finding
As reported in the abstract
LLDAS vs physician assessment
Patients in LLDAS
304
62.7%
Remission or low activity per physician assessment
430
86.1%
Overall agreement
71.4%
95% CI 70.1, 70.5
Cohen's κ (IQR 0.22-0.37)
0.3
Observational data: associations, not effects.
Further findings
Physician classification by LLDAS status
- LLDAS patients classified as remission or low activity by expert
- 96.1%
- Non-LLDAS patients classified as remission/low disease activity
- 126 (70.4%)
- Main reasons for discrepancy: new manifestations vs previous visit and SLEDAI-2K >4, mainly serological activity
Original publication
Does expert opinion match the definition of lupus low disease activity state? Prospective analysis of 500 patients from a Spanish multicentre cohort. Rheumatology (Oxford). Published 12 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →