Lupus & antiphospholipid syndrome
The impact of disease activity and interferon-α on the nervous system in systemic lupus erythematosus
Main finding · More cognitive dysfunctionResult — go to the resultOdds ratio 11.0Authors' conclusion
The study suggests that disease activity and IFN-α may drive neuronal affliction in SLE, also in the absence of overt neuropsychiatric symptoms
Study context
- Population
- Consecutive female systemic lupus erythematosus (SLE) outpatients, Lund Lupus Cohort
- Participants
- 24 / 33 / 31 / 35
- Exposure
- High vs low interferon (IFN)-α lupus phenotype; moderate-high vs low SLEDAI-2K lupus phenotype
- High IFN-αn = 24
- Low IFN-αn = 33reference
- Moderate-high SLEDAI-2 Kn = 31
- Low SLEDAI-2 Kn = 35reference
- Outcome
- Neuronal impairment: plasma NfL concentrations, structural magnet resonance imaging (MRI) alterations, and cognitive dysfunction (CNS-Vital Signs)
Methodological detailsconsecutive outpatients, multivariate linear mixed-effect, linear and logistic regression models
- Consecutive outpatients
- Multivariate linear mixed-effect, linear and logistic regression models
Main finding
More cognitive dysfunction
Odds ratio
11.0
P = 0.004
As reported in the abstract
- Visits with higher disease activity associated with higher plasma neurofilament light (NfL) concentrations (SLEDAI-2K total)
- P = 1.5*10- 6
- High vs low IFN-α: smaller total grey matter volume
- P = 0.036
- High vs low IFN-α: smaller caudate nucleus volume
- P = 0.038
- High vs low IFN-α: smaller thalamus volume
- P = 0.023
- Moderate-high vs low SLEDAI-2K: larger white matter lesion volumes
- P = 0.011
- Moderate-high vs low SLEDAI-2K: smaller total grey matter volume
- P = 0.041
- Moderate-high vs low SLEDAI-2K: smaller thalamus volume
- P = 0.005
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The impact of disease activity and interferon-α on the nervous system in systemic lupus erythematosus. Arthritis Res Ther. Published 20 March 2025. doi:10.
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