Lupus & antiphospholipid syndrome
Race, Ethnicity, and Disparities in the Risk of End‐Organ Lupus Manifestations Following a Systemic Lupus Erythematosus Diagnosis in a Multiethnic Cohort
Authors' conclusion
We found heightened risks of developing renal, hematologic, and multiorgan disease following SLE diagnosis among Hispanic and Asian patients with SLE, as well as a high burden of multiorgan disease among CLUES participants.
Study context
- Population
- Participants with systemic lupus erythematosus (SLE) in the California Lupus Epidemiology Study (CLUES); 89% female, mean age 45 years30% White, 23% Hispanic, 11% Black, 36% Asian
- Participants
- 326 participants
- Exposure
- Hispanic, Black and Asian vs White participants with SLE
- Outcome
- Major end-organ lupus manifestations (renal, hematologic, neurologic, cardiovascular, pulmonary) and multiorgan disease (≥2 organ systems) following SLE diagnosis
Methodological detailslongitudinal, multiethnic, Kaplan-Meier, Cox proportional hazards regression adjusted for age at diagnosis, sex, and race and ethnicity
- Longitudinal
- Multiethnic
- Kaplan-Meier
- Cox proportional hazards regression adjusted for age at diagnosis, sex, and race and ethnicity
Main finding
As reported in the abstract
Renal disease following SLE diagnosis
Each group vs whiteHazard ratio (95% CI)
Hispanic
2.9(1.8–4.7)
Asian
2.9(1.9–4.6)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Hematologic disease following SLE diagnosisHispanicvs White | 2.7 (1.3–5.7) | |
| Hematologic disease following SLE diagnosisAsianvs White | 2.1 (1.0–4.2) | |
| Multiorgan disease following SLE diagnosisHispanicvs White | 3.3 (1.8–5.9) | |
| Multiorgan disease following SLE diagnosisAsianvs White | 2.5 (1.4–4.4) | |
| 0.20.5125Hazard ratio (log scale) |
- Multiorgan disease following SLE diagnosis — Multiorgan disease, whole cohort
- 29%
Original publication
Race, Ethnicity, and Disparities in the Risk of End‐Organ Lupus Manifestations Following a Systemic Lupus Erythematosus Diagnosis in a Multiethnic Cohort. Arthritis Care Res (Hoboken). Published 15 August 2022. doi:10.
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