Lupus & antiphospholipid syndrome
Antiphospholipid antibodies in patients with calcific aortic valve stenosis
Authors' conclusion
aPL IgG was more common in CAVS patients compared with matched controls and aPL positivity was associated with altered AV transcriptomics related to local disease progression and interferon pathways.
Study context
- Population
- Patients with tricuspid calcific aortic valve stenosis and age- and sex-matched controls233 calcific aortic valve stenosis (CAVS) cases
- Comparison
- Tricuspid CAVS cases vs age- and sex-matched controls
- CAVSn = 233
- Outcome
- Prevalence of aPL (anti-cardiolipin and anti-β2Glycoprotein-I, IgG/M/A) and other SLE-associated autoantibodies
Methodological detailsage- and sex-matched controls, microarray transcriptomic analysis, supervised machine learning
- Age- and sex-matched controls
- Microarray transcriptomic analysis
- Supervised machine learning
Main finding
As reported in the abstract
Positivity for any aPL (IgG/M/A) in CAVS
CAVS
6.4%
95% CI 3.6%–10.4%
Observational data: associations, not effects.
Further findings
aPL IgG prevalence
P = 0.04
Aortic valve (AV) tissue transcriptomics (5 aPL positive vs 5 matched aPL negative CAVS patients undergoing surgical AV replacement)
- Differentially expressed genes predicting local AV CAVS progression with supervised machine learning
- 100
- AV tissue from aPL IgG/IgM-positive patients negatively enriched in interferon signalling pathways
Original publication
Antiphospholipid antibodies in patients with calcific aortic valve stenosis. Rheumatology (Oxford). Published 12 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →