Lupus & antiphospholipid syndrome
In-hospital outcomes of patients with antiphospholipid syndrome undergoing transcatheter and surgical aortic valve replacement: A population-based analysis of national inpatient sample from 2015–2021
Authors' conclusion
APS patients had all comparable outcomes after TAVR, while they had higher risks of PE and AKI after SAVR.
Study context
- Population
- Adults (≥18 years) undergoing TAVR or surgical aortic valve replacement (SAVR) without concomitant procedures, National Inpatient Sample, Q4 2015–2021, United Statesafter propensity-score matching
- Participants
- 100 / 504 / 119 / 581
- Exposure
- Antiphospholipid syndrome (APS) vs non-APS patients undergoing TAVR and SAVR
- APS (TAVR)n = 100
- Non-APS (TAVR)n = 504reference
- APS (SAVR)n = 119
- Non-APS (SAVR)n = 581reference
- Outcome
- In-hospital outcomes
- Follow-up
- In-hospital
Methodological detailspopulation-based, National Inpatient Sample, 1:5 propensity-score matching in TAVR and SAVR separately
- Population-based
- National Inpatient Sample
- 1:5 propensity-score matching in TAVR and SAVR separately
Main finding
As reported in the abstract
- TAVR: all outcomes between APS and non-APS patients were comparable
- Propensity-score matched
Observational data: associations, not effects.
Safety
| Outcome | APS (SAVR) | Non-APS (SAVR) | P value |
|---|---|---|---|
| PE after SAVR · in-hospitalAPS (SAVR) vs Non-APS (SAVR) · propensity-score matched | 5.13% | 0.86% | P < 0.01 |
| Acute kidney injury after SAVR · in-hospitalAPS (SAVR) vs Non-APS (SAVR) · propensity-score matched | 35.04% | 22.55% | P = 0.01 |
Original publication
In-hospital outcomes of patients with antiphospholipid syndrome undergoing transcatheter and surgical aortic valve replacement: A population-based analysis of national inpatient sample from 2015–2021. Lupus. Published 19 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →