Lupus & antiphospholipid syndrome
Time Trends in Acute Coronary Syndrome Hospitalizations and Outcomes in Patients With Systemic Lupus Erythematosus: A United States Inpatient Cohort Analysis
Authors' conclusion
SLE patients with ACS require higher healthcare utilization, with longer hospital stays and higher charges. Although ACS hospitalization rates declined for both groups, the decrease was greater in patients without SLE.
Study context
- Population
- Acute Coronary Syndrome (ACS) hospitalizations in the US National Inpatient Sample, 2006–2019
- Participants
- 17,318,554 ACS hospitalizations
- Exposure
- ACS hospitalizations with systemic lupus erythematosus (SLE) vs without SLE
- SLEn = 70,882
- Outcome
- Trends in ACS hospitalizations; in-hospital mortality, LOS and charges
Methodological detailsUS National Inpatient Sample, 2006-2019, ICD-9 and ICD-10 codes
- US National Inpatient Sample, 2006-2019
- ICD-9 and ICD-10 codes
Main finding
As reported in the abstract
ACS hospitalization rates fell from 2006 to 2019 in SLE (mainly 2015-2019)
40%
ACS hospitalization rates fell from 2006 to 2019 without SLE
50%
Observational data: associations, not effects.
Further findings
In-hospital mortality
P = 0.52
LOS
P < 0.001
Hospital charges
P < 0.001
Original publication
Time Trends in Acute Coronary Syndrome Hospitalizations and Outcomes in Patients With Systemic Lupus Erythematosus: A United States Inpatient Cohort Analysis. J Rheumatol. Published 15 November 2025. doi:10.
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