Lupus & antiphospholipid syndrome
Right heart failure outcomes in systemic lupus erythematosus: Cardiovascular insights from a nationwide inpatient study
Main finding · All-cause mortalityResult — go to the resultAdjusted odds ratio 3.8 95% CI 1.19–12.29Authors' conclusion
Among RHF hospitalizations SLE is associated with higher mortality and non-fatal adverse outcomes.
Study context
- Population
- Right heart failure hospitalizations, 2016–2019 National Inpatient Sample
- Participants
- 5,569 Right Heart Failure (RHF) hospitalizations
- Exposure
- RHF hospitalizations with vs without Systemic Lupus Erythematosus (SLE)
- SLEn = 111
- Outcome
- All-cause mortality (in-hospital)
Methodological detailsnationwide inpatient database (National Inpatient Sample 2016-2019), multivariable and linear regression adjusted for demographics and comorbidity burden
- Nationwide inpatient database (National Inpatient Sample 2016-2019)
- Multivariable and linear regression adjusted for demographics and comorbidity burden
Main finding
All-cause mortality
Adjusted odds ratio
3.8
95% CI 1.19–12.29
SLEvs Without SLE
aOR 3.8 (95% CI 1.19–12.29)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| AKI | 2.61 (1.05–6.52) | |
| Vasopressor use | 8.11 (2.20–29.8) | |
| Mechanical ventilation useNo difference observed | 1.39 (0.35–5.5) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Mean LOS
P = 0.436
| Outcome | SLE | Without SLE | P value |
|---|---|---|---|
| Total hospitalization charges | $258,475 | $86,910 | P = 0.301 |
Original publication
Right heart failure outcomes in systemic lupus erythematosus: Cardiovascular insights from a nationwide inpatient study. Lupus. Published 31 August 2025. doi:10.
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