Lupus & antiphospholipid syndrome
Association of antiphospholipid syndrome with infective endocarditis and sepsis induced by Staphylococcus aureus: A U.S. nationwide inpatient sample analysis
Main finding · IEResult — go to the resultAdjusted odds ratio 2.03 95% CI 1.22–3.37Authors' conclusion
APS emerged as a significant independent risk factor for IE, Methicillin-resistant (MRSA), and Methicillin-sensitive Staphylococcus aureus (MSSA) sepsis.
Study context
- Population
- Hospitalized patients aged 18–75, US National Inpatient Sample 2016–2020; major pre-existing infective endocarditis (IE) risks or significant confounders (e.g., prosthetic valves, specific congenital/rheumatic heart diseases, ESRD) excluded
- Participants
- 297,459 patients
- Exposure
- APS vs no APS
- Outcome
- Infective endocarditis (IE)
Methodological detailsNational Inpatient Sample (NIS) 2016–2020, multivariable logistic regression
- National Inpatient Sample (NIS) 2016–2020
- Multivariable logistic regression
Main finding
IE
Adjusted odds ratio
2.03
95% CI 1.22–3.37
APSvs No APS
aOR 2.03 (95% CI 1.22–3.37)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| MRSA sepsis | 1.75 (1.18–2.58) | |
| MSSA sepsis | 1.86 (1.28–2.70) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Original publication
Association of antiphospholipid syndrome with infective endocarditis and sepsis induced by Staphylococcus aureus: A U.S. nationwide inpatient sample analysis. Lupus. Published 8 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →