Lupus & antiphospholipid syndrome
Autoimmune encephalitis associated with anti-LGI1 antibody: a potential cause of neuropsychiatric systemic lupus erythematosus
Study context
- Population
- Patients with SLE suspected of autoimmune encephalitis, October 2014 to April 20244 anti-LGI1 positive
- Participants
- 332 patients
- Outcome
- Clinical features and treatment outcomes of anti-LGI1 encephalitis in SLE
Methodological detailsretrospective screening cohort, cell-based assays
- Retrospective screening cohort
- Cell-based assays
Main finding
As reported in the abstract
- Anti-LGI1 antibody positive
- 4
- Signs of limbic encephalitis (short-term memory deficits, seizures, psychiatric disturbances)
- 4
- Faciobrachial dystonic seizures
- 2
- Hyperintense basal ganglia lesions on MRI
- 2
- Significant improvement with corticosteroids, IV immunoglobulin and MMF, no relapses during follow-up of 33 to 60 months
- 3
- Death from pneumonia despite initial improvement of neurological function
- 1
Observational data: associations, not effects.
Original publication
Autoimmune encephalitis associated with anti-LGI1 antibody: a potential cause of neuropsychiatric systemic lupus erythematosus. Lupus Sci Med. Published 18 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →