Lupus & antiphospholipid syndrome
Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus
Main finding · All-cause mortalityResult — go to the resultHazard ratio 3.71 95% CI 1.82–7.54Authors' conclusion
An FI constructed exclusively from routinely collected laboratory variables can measure frailty and predict adverse outcomes in SLE.
Study context
- Population
- Adult patients with systemic lupus erythematosus (SLE), single-center prospective cohort, baseline visit 2010–2019 (89% women, mean age 47.7 years)
- Participants
- 283 patients
- Exposure
- Frail vs nonfrail patients with SLE
- Frailn = 97
- Outcome
- All-cause mortality and organ damage accrual
Methodological detailssingle-center, Cox proportional hazards regression, negative binomial regression
- Single-center
- Cox proportional hazards regression
- Negative binomial regression
Main finding
All-cause mortality
Hazard ratio
3.71
95% CI 1.82–7.54
Frailvs Nonfrail
HR 3.71 (95% CI 1.82–7.54)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | |
|---|---|---|
| Organ damage accrual during follow-up | 2.26 (1.59–3.22) | |
| 0.20.5125Incidence rate ratio (log scale) |
Organ damage accrual during follow-up
- Both indices significant baseline predictors of organ damage accrual; model with both FIs outperformed models with either index alone
Original publication
Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 5 May 2026. doi:10.
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