Lupus & antiphospholipid syndrome
Controlling cardiovascular risk factors reduces progression of atherosclerosis in a multiethnic cohort of patients with lupus
Authors' conclusion
In this ethnically diverse (40% non-Caucasian) population, we confirmed earlier findings that better control of CVD risk targets reduces progression of atherosclerotic plaque. Anti-La positivity was associated with less plaque progression, which was unexpected.
Study context
- Population
- Ethnically diverse (40% non-Caucasian) cohort of patients with SLE
- Participants
- 69 participants
- Outcome
- Change in plaque number and increase in total plaque area (TPA) between scans
- Follow-up
- Second scan (mean 63 months apart)
Methodological detailsrepeat carotid and common femoral US, mean 63 months apart
- Repeat carotid and common femoral US, mean 63 months apart
Main finding
As reported in the abstract
Plaque progression between scans · second scan
Patients with plaque at second scan
31
Unchanged number of plaques
13
Increased plaque numbers (including six initially free of plaque)
18
Median total plaque area (TPA) increase in the 31 patients with plaque (IQR 2.4-7.33)
4.59 mm²/year
Observational data: associations, not effects.
Original publication
Controlling cardiovascular risk factors reduces progression of atherosclerosis in a multiethnic cohort of patients with lupus. Lupus Sci Med. Published 4 May 2026. doi:10.
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