Lupus & antiphospholipid syndrome
Primary antiphospholipid syndrome with and without limb ischemia: A retrospective observational study
Authors' conclusion
PAPS and LI have a distinct clinical and laboratory spectra from those without LI and it is characterized by an increased frequency of protein C deficiency, and a lower frequency of venous events, deep venous thrombosis and IgM anticardiolipin.
Study context
- Population
- Patients with primary APS (83.3% female)
- Participants
- 66 patients
- Exposure
- PAPS with limb ischemia (LI) vs PAPS without LI
- Outcome
- Clinical and laboratory features, PAPS with LI vs without LI
Methodological detailsretrospective, observational
- Retrospective
- Observational
Main finding
As reported in the abstract
- Longer disease duration in PAPS with LI
- p = .012
- More arterial events in PAPS with LI
- p = .002
- Lower frequency of venous events in PAPS with LI
- p = .007
- Lower frequency of DVT in PAPS with LI
- p = .016
- More protein C deficiency in PAPS with LI
- p = .015
Observational data: associations, not effects.
Original publication
Primary antiphospholipid syndrome with and without limb ischemia: A retrospective observational study. Lupus. Published 18 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →