Lupus & antiphospholipid syndrome
Effect of hydroxychloroquine on pregnancy outcome in patients with systemic lupus erythematosus (SLE): a systematic review and meta-analysis
Authors' conclusion
This meta-analysis offers a comprehensive assessment of the relationship between disease activity, pregnancy-related outcomes and HCQ use, providing supportive evidence for the therapeutic effectiveness of HCQ in pregnant women with SLE.
Study context
- Population
- Pregnant women with SLE; PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Wanfang and VIP searched from inception to 22 September 202221 studies
- Participants
- 929 vs 1,031
- Comparison
- Hydroxychloroquine (HCQ) use vs no HCQ during pregnancy in women with SLE
- HCQn = 929
- non-HCQn = 1,031reference
- Outcome
- Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores, HCQ vs non-HCQ
- Follow-up
- Second and third trimester
Methodological detailsrandom or fixed effect models based on I2 heterogeneity
- Random or fixed effect models based on I2 heterogeneity
Pooled result
As reported in the abstract
HCQ vs Non-HCQMD (95% CI)
Second trimester
−1.80(−2.46 to −1.13)
Third trimester
−2.30(−3.31 to −1.29)
Original publication
Effect of hydroxychloroquine on pregnancy outcome in patients with SLE: a systematic review and meta-analysis. Lupus Sci Med. Published 30 October 2024. doi:10.
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