Lupus & antiphospholipid syndrome
Lymphadenopathy in systemic lupus erythematosus: no microbial trigger found by shotgun metagenomics in a retrospective study on 38 patients
Authors' conclusion
Despite suggestion that certain microorganisms may play a role in the pathogenesis and flares of SLE, our microbial metagenomic analysis study did not highlight possible infectious triggering factors.
Study context
- Population
- Patients with SLE who had lymph node biopsy at baseline or during follow-up
- Participants
- 38 patients
- Outcome
- Microbial metagenomic analysis of lymph node biopsy
Methodological detailsmonocentric, shotgun metagenomics
- Monocentric
- Shotgun metagenomics
Main finding
As reported in the abstract
- Absence of microbial DNA
- 92%
- CMV in very small quantities
- 2 patients
- HHV-7 in low quantities
- a single patient
Observational data: associations, not effects.
Further findings
Lymph node pathology
- Follicular and/or paracortical hyperplasia
- 73.7%
- Histiocytic necrotizing lymphadenitis
- 23.7%
Clinical features at biopsy · at the time of biopsy
- Fever
- 29%
- Splenomegaly
- 10%
- Cutaneous manifestations
- 47%
- Polyarthritis
- 32%
- Serositis
- 13%
- LN
- 18%
Laboratory features
- Increased CRP
- 50%
- Low C3
- 35%
- Hypergammaglobulinemia
- 65%
Original publication
Lymphadenopathy in systemic lupus erythematosus: no microbial trigger found by shotgun metagenomics in a retrospective study on 38 patients. Rheumatology (Oxford). Published 28 October 2024. doi:10.
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