Lupus & antiphospholipid syndrome
Systematic review of treatments for the gastrointestinal manifestations of systemic lupus erythematosus
Authors' conclusion
This review highlights the need for standardised disease definitions and terminology, as well as consideration of including gastrointestinal manifestations in disease scoring systems.
Study context
- Population
- Patients with gastrointestinal manifestations of SLE
- Participants
- 767 patients29 studies
- Outcome
- Treatment of gastrointestinal manifestations of SLE
Methodological detailssearches of MEDLINE, EMBASE, PubMed and Cochrane, January 1990 to June 2022, case series <10 cases and case reports excluded where sufficient evidence; included for rarer manifestations
- Searches of MEDLINE, EMBASE, PubMed and Cochrane, January 1990 to June 2022
- Case series <10 cases and case reports excluded where sufficient evidence; included for rarer manifestations
Pooled result
As reported in the abstract
- Most studies demonstrated a benefit from pulsed IV methylprednisolone (intravenous methylprednisolone (IVMP)) in severe or life-threatening manifestations, and oral prednisolone for less severe manifestations
- Quality of evidence low, with high risk of bias in all studies
Further pooled results
Studies by gastrointestinal manifestation
- Enteritis
- 5 studies
- Mesenteric vasculitis
- 3 studies
- Acute pancreatitis
- 5 studies
- Chronic pancreatitis
- 1 study
- Intestinal pseudo-obstruction (IPO)
- 2 studies
- Hepatitis
- 4 studies
- Protein-losing enteropathy (PLE)
- 6 studies
- Acute acalculous cholecystitis
- 2 studies
- Budd-Chiari Syndrome
- 1 study
- Ascites (13 case reports), peritonitis (3 case reports) and miscellaneous GI manifestations (11 case reports) in supplemental file
Included study designs
- Cohort studies
- six
- Case-control studies
- 11
- Case series
- 11
Original publication
Systematic review of treatments for the gastrointestinal manifestations of systemic lupus erythematosus. Semin Arthritis Rheum. Published 28 October 2024. doi:10.
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