Lupus & antiphospholipid syndrome
Impact of baseline proteinuria level on long-term outcomes in lupus nephritis
Authors' conclusion
Low-level proteinuria is commonly associated with proliferative LN and adverse long-term outcomes.
Study context
- Population
- Patients with first biopsy-proven lupus nephritis (LN)median follow-up 8.4 years
- Participants
- 249 patients
- Exposure
- Low-level vs moderate-level vs high-level baseline proteinuria
- Group 1n = 62reference
- Group 2n = 90
- Group 3n = 97
- Outcome
- Adverse composite outcome:
- ESKD
- Sustained ≥40% decline in eGFR
- Death
- Follow-up
- Median 8.4 years
Methodological detailsCox proportional hazard models, multivariable model
- Cox proportional hazard models
- Multivariable model
Main finding
As reported in the abstract
Group 1
27.4%
P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| LN flares · median follow-up 8.4 yearsGroup 1 vs Group 2 · across groups 1, 2 and 3 | P < 0.001 |
Complete proteinuria recovery (CPR) at 1 year
- Rate of CPR at 1 year highest for group 1 and lowest for group 3
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of baseline proteinuria level on long-term outcomes in lupus nephritis. Rheumatology (Oxford). Published 24 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →