Lupus & antiphospholipid syndrome
Attainment of early targets does not ensure a complete response at 12 months in lupus nephritis, especially in nephrotic-range proteinuria
Authors' conclusion
Failure to achieve the EULAR 3- and 6-month proteinuria targets serves as a warning sign for suboptimal response at 12 months. In patients with baseline nephrotic-range proteinuria attainment of early response has limited predictive value for 12-month CRR.
Study context
- Population
- Patients with biopsy-proven LN92 (69.7%) achieved complete renal response (CRR)
- Participants
- 132 patients
- Exposure
- Attainment vs non-attainment of EULAR 3- and 6-month proteinuria-reduction targets
- Outcome
- CRR at 12 months
- Follow-up
- 12 months
Main finding
As reported in the abstract
Association of EULAR target attainment with 12-month CRR, and target performance
Odds ratio (95% CI)
EULAR 3-month target
7.38(2.84–20.4)
EULAR 6-month target
10.6(3.74–32.4)
- Sensitivity, both targets (range)
- 86-89%
- Specificity, both targets (range)
- 40-45%
- Negative likelihood ratio, both targets (range)
- 0.27-0.31
Observational data: associations, not effects.
Further findings
| Outcome | EULAR 3-month target | EULAR 6-month target |
|---|---|---|
| Specificity in nephrotic-range proteinuria (subgroup) · 12 months | ||
| Specificity | 0.30 | 0.17 |
- Specificity in nephrotic-range proteinuria (subgroup): limited ability to predict 12-month CRR
Baseline proteinuria and 12-month CRR
- Higher baseline proteinuria inversely associated with CRR, OR per 1 g increase (3-month model)
- 0.77
- Higher baseline proteinuria inversely associated with CRR, OR per 1 g increase (6-month model)
- 0.75
Original publication
Attainment of early targets does not ensure a complete response at 12 months in lupus nephritis, especially in nephrotic-range proteinuria. Rheumatology (Oxford). Published 12 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →