Lupus & antiphospholipid syndrome
Does baseline nephrotic range proteinuria determine the long-term outcomes of membranous lupus nephritis patients??: Nephrotic Range Proteinuria in Membranous Lupus Nephritis
Authors' conclusion
No significant differences in renal disease characteristics or long-term outcomes were found between MLN patients with nephrotic and subnephrotic baseline proteinuria.
Study context
- Population
- Patients with biopsy-proven membranous LN (membranous lupus nephritis (MLN))
- Participants
- 88 patients
- Exposure
- Nephrotic vs subnephrotic baseline proteinuria in membranous LN
- Nephroticn = 39
- Subnephroticn = 49reference
- Outcome
- Adverse composite outcome:
- End-stage kidney disease
- Sustained ≥30 % decline in eGFR
- Death
Methodological detailsKaplan-Meier curves, Cox regression
- Kaplan-Meier curves
- Cox regression
Main finding
As reported in the abstract
Adverse composite outcome
P = 0.78
Observational data: associations, not effects.
Further findings
LN flares · no difference between groups
P = 1.00
Baseline proteinuria, median
LN flares
- Overall: flares in 35 patients (39.8 %)
Baseline characteristics
- Subnephrotic: longer time to LN onset, less frequent hyperlipidemia, higher serum albumin, less diffuse podocyte effacement, less frequent CYC treatment
- No significant differences in kidney function, urine sediment abnormalities or histopathology
Original publication
Does baseline nephrotic range proteinuria determine the long-term outcomes of membranous lupus nephritis patients??: Nephrotic Range Proteinuria in Membranous Lupus Nephritis. Semin Arthritis Rheum. Published 16 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →