Lupus & antiphospholipid syndrome
Clinical significance of anti-lipoprotein lipase antibodies in Japanese patients with systemic lupus erythematosus
Authors' conclusion
In this study, the positivity rate of anti-LPL antibodies was high among Japanese patients with SLE. Additionally, a significantly higher incidence of CV events was observed in the anti-LPL antibody-positive group compared to that in the anti-LPL antibody-negative group.
Study context
- Population
- Japanese patients with systemic lupus erythematosus (SLE) examined for anti-lipoprotein lipase (anti-LPL) antibodies via western blotting
- Exposure
- Anti-LPL antibody-positive vs anti-LPL antibody-negative SLE
- Anti-LPL antibody-positiven = 28
- Outcome
- Association of anti-LPL antibodies with clinical and serological characteristics and CV events
Methodological detailsData on laboratory findings and cardiovascular (CV) events retrospectively collected
- Data on laboratory findings and CV events retrospectively collected
Main finding
As reported in the abstract
Anti-LPL antibody IgG positivity
Anti-LPL antibody-positive
35.0%
28
Observational data: associations, not effects.
Further findings
Incidence of CV events
P = 0.001
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incidence of CV eventsRisk of CV events | 169.20 (5.75–4981.54) | P = 0.003 | |
| 0.050.21520Hazard ratio (log scale) |
Triglyceride levels
- Tended to be higher in anti-LPL antibody-positive than negative
Serum albumin, anti-Smith antibody and IgM
- Significantly higher in anti-LPL antibody-positive than negative
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical significance of anti-lipoprotein lipase antibodies in Japanese patients with systemic lupus erythematosus. Lupus. Published 15 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →