Lupus & antiphospholipid syndrome
Short- and long-term outcomes of patients with pure membranous lupus nephritis compared with patients with proliferative disease
Authors' conclusion
The resolution of proteinuria in LN is slow. MLN is not a benign disease and may be associated with deterioration of renal function, ESKD, damage, CV events and death.
Study context
- Population
- Patients with first biopsy-proven membranous or proliferative LN
- Participants
- 215 patients
- Exposure
- Pure membranous LN vs proliferative LN
- Membranous LN (MLN)n = 51
- Proliferative LN (PLN)n = 164reference
- Outcome
- Short-term outcomes: CPR, CRR and PERR
- Follow-up
- 1 and 2 years
Methodological detailsunivariable and multivariable Cox proportional hazard models
- Univariable and multivariable Cox proportional hazard models
Main finding
As reported in the abstract
- No significant differences between the two groups in achieving complete proteinuria recovery (CPR), complete renal response (CRR) and primary efficacy renal response (PERR) at 1 and 2 years
- Median time to outcomes slightly, but insignificantly, longer in the MLN group
Observational data: associations, not effects.
Further findings
Long-term renal and non-renal outcomes
- PLN associated with worse renal and non-renal outcomes, not statistically significant
Baseline variables associated with end-stage kidney disease (ESKD) (multivariable Cox)
- Younger age, HR
- 0.92 (95% CI 0.87-0.97)
- Higher creatinine, HR
- 1.01 (95% CI 1.01-1.02)
- Low complement, HR
- 4.0 (95% CI 1.04-11.10)
- Higher chronicity index, HR
- 1.28 (95% CI 1.08-1.51)
Original publication
Short- and long-term outcomes of patients with pure membranous lupus nephritis compared with patients with proliferative disease. Rheumatology (Oxford). Published 12 August 2024. doi:10.
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