Lupus & antiphospholipid syndrome

Seroprevalence of Toxoplasma gondii immunoglobulins and its association with systemic lupus erythematosus: A systematic review and meta-analysis

LupusPublished Systematic review and meta-analysis

Pooled result · T. gondii IgG seropositivityResult — go to the resultRelative risk 2.14 95% CI 1.42–3.22

Authors' conclusion

In summary, this study suggests that T. gondii IgG is more prevalent in patients with SLE than in healthy individuals in areas where T. gondii infections are more frequent.

Study context

Population
Published studies of T. gondii antibodies in patients with systemic lupus erythematosus (SLE) and controls11 studies
Comparison
SLE vs healthy controls
Outcome
Association between T. gondii seropositivity and SLE

Pooled result

T. gondii IgG seropositivity

Relative risk

2.14

95% CI 1.42–3.22

P = 0.000

SLEvs Healthy controls
RR 2.14 (95% CI 1.42–3.22); P = 0.000

As reported in the abstract

Further pooled results

T. gondii IgM seropositivity

Comparable between patients with SLE and healthy controls

Prevalence of anti-T. gondii antibodies in SLE

IgG prevalence
33.9%
IgM prevalence
7.7%

Original publication

Seroprevalence of Toxoplasma gondii immunoglobulins and its association with systemic lupus erythematosus: A systematic review and meta-analysis. Lupus. Published 11 August 2024. doi:10.1177/09612033241273048

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