Lupus & antiphospholipid syndrome
Reduction in Renal Relapse and Preservation of Long‐Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis
Authors' conclusion
LLDAS is an attainable target in LN comparable to CRR/PRR. Attainment of both targets is associated with additional benefits on relapse risk reduction. Early LLDAS attainment is associated with renal function preservation.
Study context
- Population
- Patients with Lupus Nephritis (LN) during 2010 to 2020 in Queen Mary Hospital and Pamela Youde Nethersole Eastern Hospital
- Participants
- 245 patients
- Exposure
- Attainment vs non-attainment of lupus low disease activity state (LLDAS) and complete renal response (CRR)/partial renal response (PRR) at 12 months
- Discoveryn = 143
- Validationn = 102
- Outcome
- Frequency of LLDAS attainment and its benefit on LN relapse and renal function preservation
- Follow-up
- 12 months
Methodological detailsdiscovery and validation cohorts, two hospitals, multivariate regression, ROC analysis
- Discovery and validation cohorts
- Two hospitals
- Multivariate regression
- ROC analysis
Main finding
As reported in the abstract
Target attainment, discovery cohort
CRR
57 of 143
40%
PRR
14 of 143
10%
LLDAS
70 of 143
49%
Definition Of Remission In SLE (DORIS) remission
15 of 143
10%
Observational data: associations, not effects.
Further findings
LN relapse risk (multivariate analysis)
| HR | P value | |
|---|---|---|
| CRR/PRRIndependent association | 0.31 | P = 0.007 |
| LLDASIndependent association | 0.38 | P = 0.029 |
Relapse-free survival with attainment of both CRR/PRR and LLDAS at 12 months
- Attainment of both associated with best relapse-free survival
- P < 0.001
LLDAS attainment predicting renal function preservation, discovery and validation cohorts
- AUC of the ROC
- 0.71
Original publication
Reduction in Renal Relapse and Preservation of Long‐Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis. Arthritis Care Res (Hoboken). Published 21 November 2025. doi:10.
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