Lupus & antiphospholipid syndrome
Development and validation of nomograms for predicting activity index and tubulointerstitial lesions in lupus nephritis: a multicentre study
Authors' conclusion
The developed nomograms provide reliable, non-invasive tools for identifying patients with LN with high AI and TIL
Study context
- Population
- Patients with lupus nephritis (LN) diagnosed by kidney biopsy from three centres
- Participants
- 266 patients3 centres
- Comparison
- Training vs Validation
- Trainingn = 213
- Validationn = 53
- Outcome
- High AI (AI >4) and high TIL (TIL >4)
Methodological detailsmulticentre, training and validation cohorts, multivariate logistic regression, nomograms
- Multicentre
- Training and validation cohorts
- Multivariate logistic regression
- Nomograms
Performance
As reported in the abstract
Independent risk factors and nomogram performance for high AI and high TIL
- Independent risk factors for high activity index (AI): lymphocyte count, haematuria, albumin, serum creatinine, complement 4 and antihistone antibodies
- Risk factors for high tubulointerstitial lesions (TIL): age, haemoglobin, platelet count, blood urea nitrogen and antiribosomal P antibodies
- Both nomograms showed favourable discrimination and calibration in both cohorts
Original publication
Development and validation of nomograms for predicting activity index and tubulointerstitial lesions in lupus nephritis: a multicentre study. Lupus Sci Med. Published 19 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →