Lupus & antiphospholipid syndrome
Myeloid‐Derived Suppressor Cell–Derived Interferon‐β Promotes T Follicular Helper Cell Response and Exacerbates Lupus Development
Authors' conclusion
These results have demonstrated a novel function of IFN-β in promoting Tfh cell response during lupus progression
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and lupus mice
Methodological detailspatient correlation analysis, lupus mouse models, Ifnar1-/- mice, adoptive transfer, in vitro culture
- Patient correlation analysis
- Lupus mouse models
- Ifnar1-/- mice
- Adoptive transfer
- In vitro culture
Main finding
As reported in the abstract
- Increased T follicular helper (Tfh) cells with IFN-I-inducible gene signatures correlated with disease activities in patients with SLE
- Interferon (IFN)-β treatment markedly enhanced Tfh cell response and exacerbated disease progression in lupus mice
- IFNAR1 deficiency: attenuated lupus progression with significantly decreased Tfh response
- IFN-β activated the IDO/Kyn/AhR axis to promote Tfh cell differentiation
- Expanded myeloid-derived suppressor cells (MDSCs) in lupus produced high levels of IFN-β
- Activated lymphocyte-derived DNA stimulated IFN-β production by MDSCs via cyclic GMP-AMP synthase-stimulator of IFN genes (cGAS-STING)-dependent pathway
Original publication
Myeloid‐Derived Suppressor Cell–Derived Interferon‐β Promotes T Follicular Helper Cell Response and Exacerbates Lupus Development. Arthritis Rheumatol. Published 11 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →