Lupus & antiphospholipid syndrome
Interleukin‐12 Signaling Promotes Podocyte Senescence in Lupus Nephritis
Authors' conclusion
Our findings identify IL-12 signaling as an important mediator of podocyte senescence in LN
Study context
- Population
- Patients with SLE (including lupus nephritis (LN)) and healthy controls; lupus-prone and nephrotoxic nephritis mouse models
- Participants
- 39 / 15 / 13
- Comparison
- Podocyte-specific Il12rb1 knockout mice vs B6.Il12rb1fl/fl and B6.lpr.Il12rb1fl/fl controls; patients with SLE/LN vs healthy controls
- SLEn = 39
- LNn = 15
- Healthy controlsn = 13reference
- Outcome
- IL-12 signalling and podocyte senescence in LN (serum IL-12, podocyte IL-12R expression, effects of IL-12 and of podocyte-specific Il12rb1 deletion)
Methodological detailshuman sera and kidney tissue, immortalized human podocyte cell line in vitro, podocyte conditional Il12rb1 knockout mice, accelerated lupus model and nephrotoxic nephritis model
- Human sera and kidney tissue
- Immortalized human podocyte cell line in vitro
- Podocyte conditional Il12rb1 knockout mice
- Accelerated lupus model and nephrotoxic nephritis model
Main finding
As reported in the abstract
- Serum IL-12 elevated in patients with LN
- P = 0.006
- Serum IL-12 elevated in lupus-prone mice
- P = 0.041
Original publication
Interleukin‐12 Signaling Promotes Podocyte Senescence in Lupus Nephritis. Arthritis Rheumatol. Published 24 August 2026. doi:10.
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