Lupus & antiphospholipid syndrome
Sirtuin 1 overexpression contributes to the expansion of follicular helper T cells in systemic lupus erythematosus and may serve as an accessible therapeutic target
Authors' conclusion
SIRT1 overexpression contributed to the expansion of Tfh cells in SLE and may serve as a potential target for treatment.
Study context
- Population
- SLE patients (peripheral blood Tfh cells); MRL/lpr and pristane-induced lupus mice
- Comparison
- SIRT1 overexpression, knockdown or inhibition (EX527, nicotinamide) in Tfh cell differentiation; nicotinamide vs controls in lupus mice
- Outcome
- Role of SIRT1 in Tfh cell expansion in SLE
Methodological detailshuman cells and mouse models, in vitro and in vivo
- Human cells and mouse models
- In vitro and in vivo
Main finding
As reported in the abstract
- SIRT1 expression elevated in Tfh cells from SLE patients, positively correlated with Tfh cell frequencies
- SIRT1 expression gradually increased during Tfh cell differentiation
- SIRT1 overexpression by lentiviral vectors significantly promoted Tfh cell differentiation/proliferation
- SIRT1 suppression by small interfering RNA (siRNA) and SIRT1 inhibition by EX-527 or nicotinamide hindered Tfh cell expansion
- Continuous daily nicotinamide alleviated lupus-like phenotypes and decreased serum CXCL13 in both mouse models
Original publication
Sirtuin 1 overexpression contributes to the expansion of follicular helper T cells in systemic lupus erythematosus and may serve as an accessible therapeutic target. Rheumatology (Oxford). Published 4 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →