Lupus & antiphospholipid syndrome
Multidimensional factors affecting mortality and causes of death in patients with systemic lupus erythematosus: a Finnish cohort study with more than 20 years of follow-up
Authors' conclusion
Multidimensional factors are associated with increased long-term mortality in SLE, and independent predictors include age, damage score, and renal failure.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from the Helsinki University Hospital, cohort established in the early 2000s (mean age 47.4 years)
- Participants
- 224 patients
- Outcome
- Long-term mortality and causes of death
Methodological detailssingle-centre, median follow-up 20.5 years
- Single-centre
- Median follow-up 20.5 years
Main finding
As reported in the abstract
Mortality · median follow-up 20.5 years
- Deaths
- 82 (36.6%)
- Survival at 5 years
- 94.8%
- Survival at 10 years
- 85.3%
- Survival at 20 years
- 63.1%
- Overall standardized mortality ratio
- 2.73 (95% CI 2.20-3.39)
Observational data: associations, not effects.
Further findings
Primary causes of death
- CVD
- 29 patients, 35%
- Malignancies
- 22, 27%
- SLE
- 10, 12%
- Infections as immediate cause of death
- 16 cases (20%)
Baseline factors associated with mortality (univariate)
- Age, disease duration, body mass index (BMI), education, income, damage score, comorbidities, renal failure, smoking history
Original publication
Multidimensional factors affecting mortality and causes of death in patients with systemic lupus erythematosus: a Finnish cohort study with more than 20 years of follow-up. Scand J Rheumatol. Published 2 February 2026. doi:10.
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