Lupus & antiphospholipid syndrome
Mortality and causes of death in systemic lupus erythematosus in New Zealand: a population-based study
Main finding · All-cause mortality vs general population (SMR)Result — go to the resultSMR 4.0 95% CI 3.7–4.3Authors' conclusion
The outcomes of SLE in New Zealand were still very poor compared with the general population. Māori with SLE had worse survival than others.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients in New Zealand, 2005 to 2021699 died
- Participants
- 2,802 patients
- Exposure
- SLE patients vs general population; Māori vs others
- SLEn = 2,802
- Outcome
- Mortality of SLE patients (SMR vs general population)
Methodological detailsnational administrative datasets, age-adjusted Cox proportional hazards model
- National administrative datasets
- Age-adjusted Cox proportional hazards model
Main finding
All-cause mortality vs general population (SMR)
Standardized mortality ratio (SMR)
4.0
95% CI 3.7–4.3
Events by group
SLE
24.9%
699 of 2802
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortality by ethnicityMāorivs OthersAge-adjusted | 1.72 (1.10–2.67) | |
| SLE-specific mortality by ethnicityMāorivs OthersAge-adjusted | 2.60 (1.29–5.24) | |
| 0.20.5125Hazard ratio (log scale) |
Age-standardised mortality rate of SLE, by sex
- Women
- 0.29 per 100 000
- Men
- 0.05
Deaths and SLE as underlying cause of death
- Died
- 699 (24.9%)
- SLE deaths
- 209 (29.9%)
Mean age at death
- Mean (SD) age at death
- 65.3 (17.1) years
SLE as underlying cause of death, by age
- Under 20 years old
- 78.9%
- Aged 70-79 years
- 18.7%
- Younger patients more likely to have SLE as underlying cause of death
SMR by age
- Young patients had higher SMRs than older patients
Original publication
Mortality and causes of death in systemic lupus erythematosus in New Zealand: a population-based study. Rheumatology (Oxford). Published 26 August 2023. doi:10.
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