Lupus & antiphospholipid syndrome
Responsive and monophasic lupus nephritis: prevalence, associations and outcomes
Authors' conclusion
Approximately 26% of LN patients exhibit a responsive and monophasic course.
Study context
- Population
- SLE patients from an observational cohort who developed LN at or after clinic entrymedian follow-up 10.6 years
- Participants
- 374 patients
- Outcome
- Responsive and monophasic course: complete proteinuria recovery within 1 year (subnephrotic) or 2 years (nephrotic-range proteinuria), without subsequent renal flares
Methodological detailsobservational cohort, univariable and multivariable logistic regression, Cox regression
- Observational cohort
- Univariable and multivariable logistic regression
- Cox regression
Main finding
As reported in the abstract
Responsive and monophasic LN course (proportion)
Patients with a responsive and monophasic course
96
25.7%
Observational data: associations, not effects.
Further findings
Baseline characteristics at LN onset associated with responsive and monophasic course
- Older age, OR
- 1.04 (1.01-1.07) (95% CI)
- Shorter SLE duration, OR
- 0.91 (0.86-0.97) (95% CI)
Long-term adverse composite outcome (end-stage kidney disease, sustained ≥30% estimated glomerular filtration rate (eGFR) decline, or death), Cox model
- Patients with a responsive and monophasic course who still experienced adverse events
- 18.8%
- Timely recovery of proteinuria and absence of subsequent LN flares associated with reduced risk
Original publication
Responsive and monophasic lupus nephritis: prevalence, associations and outcomes. Rheumatology (Oxford). Published 8 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →