Lupus & antiphospholipid syndrome
Immunoglobulin G (IgG) glycosylation profiling of systemic lupus erythematosus using lectin microarray
Authors' conclusion
Patients with SLE show disease-specific alterations in serum IgG glycosylation, and aberrant Galβ3GalNAc, galactose and GalNAc glycosylation may have diagnostic value for SLE and NPSLE.
Study context
- Population
- Patients with SLE, disease controls (primary Sjögren's syndrome (pSS), rheumatoid arthritis (RA)) and healthy controls
- Participants
- 194 / 40 / 60 / 100
- Exposure
- SLE vs disease controls and healthy controls; SLE subgroups
- SLEn = 194
- pSSn = 40reference
- RAn = 60reference
- Healthy controls (HCs)n = 100reference
- Outcome
- Serum IgG glycosylation profile
Methodological detailslectin microarray (56 lectins), lectin blotting validation, ROC analysis
- Lectin microarray (56 lectins)
- Lectin blotting validation
- ROC analysis
Main finding
As reported in the abstract
Serum IgG glycan levels, SLE vs DC and HC
Galβ3GalNAc significantly increased in SLE (binding Jacalin)
11.3%
Galβ3GalNAc significantly increased in SLE (binding Maclura pomifera lectin)
14.4%
Observational data: associations, not effects.
Further findings
IgG glycans in SLE subgroups
- Elevated GalNAc and galactose patterns in neuropsychiatric SLE (NPSLE) vs without major organ involvement (WMOI)
- Higher Galβ3GalNAc and galactose patterns in NPSLE and lupus nephritis (LN) vs HCs
ROC: SLE vs pSS
- PNA levels might have moderate potential for discriminating SLE from pSS
Original publication
IgG glycosylation profiling of systemic lupus erythematosus using lectin microarray. Lupus Sci Med. Published 5 April 2025. doi:10.
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