Elevated serum interferon-α2 associates with activity and flare risk in juvenile-onset systemic lupus erythematosus
Authors' conclusion
Serum IFN-α2 levels associate with disease activity and can predict ongoing and future flares in jSLE.
Study context
- Population
- Patients with juvenile-onset SLE, juvenile idiopathic arthritis (JIA) patients and healthy controls
- Participants
- 222 serum samples
- Exposure
- Serum IFN-α2 levels across juvenile systemic lupus erythematosus (jSLE) disease activity states, JIA and healthy controls
- JSLEn = 88
- JIAn = 35reference
- Healthy controls (HCs)n = 28reference
- Outcome
- Serum IFN-α2 as marker of disease activity and predictor of flares in jSLE
Methodological detailssingle-molecule array (Simoa), generalised linear mixed model
- Single-molecule array (Simoa)
- Generalised linear mixed model
Main finding
As reported in the abstract
Serum IFN-α2 by jSLE disease activity state
Active/intermediate vs LDAS: P = 0.04 · Active/intermediate vs Remission: P < 0.001
Observational data: associations, not effects.
Further findings
Serum IFN-α2, jSLE vs JIA and HCs — JSLE vs JIA
P = 0.0017
| Outcome | P value |
|---|---|
| Serum IFN-α2, jSLE vs JIA and HCsJSLE vs HCs | P = 0.017 |
- Time to flare in remission/LDAS, abnormal vs normal IFN-α2 · six months · shorter time to flare with abnormal IFN-α2
- P = 0.022
Predictor of ongoing flare (longitudinal multivariable)
- High IFN-α2 the only predictor of an ongoing flare
- P = 0.028
Original publication
Elevated serum interferon-α2 associates with activity and flare risk in juvenile-onset systemic lupus erythematosus. Rheumatology (Oxford). Published 26 November 2024. doi:10.
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