Diagnostic value of minor salivary gland biopsy for Sjögren's syndrome in children: A monocentric retrospective study over 10 years
Authors' conclusion
MSGB demonstrates good sensitivity and specificity, but the predictive values and likelihood ratios make it a poor screening test. However, when combined with other criteria such as the presence of anti-SSA antibodies, the specificity of MSGB is improved.
Study context
- Population
- Patients under 18 years old suspected of SS who had a minor salivary gland biopsy (MSGB) between October 2011 and December 2021 at Bicêtre University HospitalMSGB analysed
- Participants
- 66 participants
- Comparison
- MSGB vs MSGB + anti-SSA antibodies
- MSGBn = 66
- Outcome
- Diagnostic performance of MSGB for SS
Methodological detailsretrospective, monocentric
- Retrospective
- Monocentric
Performance
As reported in the abstract
| Test or model | Value | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|
| MSGB | 35% | 81% | 80 | 57% | 7% |
| MSGB + anti-SSA antibodies | 98% |
Value
MSGB35%
MSGB + anti-SSA antibodies— not stated in the abstract
Sensitivity
MSGB81%
MSGB + anti-SSA antibodies— not stated in the abstract
Specificity
MSGB80
MSGB + anti-SSA antibodies98%
PPV
MSGB57%
MSGB + anti-SSA antibodies— not stated in the abstract
NPV
MSGB7%
MSGB + anti-SSA antibodies— not stated in the abstract
Further findings
- Positive MSGB associated with confirmed final diagnosis
- 57% · 13
- MSGB with positive anti-SSA antibodies
- 20 · events
- Positive MSGB associated with confirmed final diagnosis: 13/23 positive biopsies
- MSGB with positive anti-SSA antibodies: 20 of 64 MSGB
Original publication
Diagnostic value of minor salivary gland biopsy for Sjögren's syndrome in children: A monocentric retrospective study over 10 years. Joint Bone Spine. Published 26 November 2024. doi:10.
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