Incidence and Genetic Risk of Juvenile Idiopathic Arthritis in Norway by Latitude
Authors' conclusion
We found a higher incidence of JIA with increasing latitude without evidence for available environmental factors explaining the observed gradient.
Study context
- Population
- All Norwegian children born 2004–2019, followed up throughout 20201,184 juvenile idiopathic arthritis (JIA)
- Exposure
- North and Mid regions vs South region of Norway
- Outcome
- JIA incidence rate per 100,000 person-years
- Follow-up
- Median 9.1 (range 0.3-16.0) years
Methodological detailsnationwide, genetic risk subsample (MoBa)
- Nationwide
- Genetic risk subsample (MoBa)
Main finding
As reported in the abstract
Each group vs southHazard ratio (95% CI)
North
2.07(1.77–2.43)
Mid
1.43(1.23–1.67)
- Incidence rate (IR) in all of Norway
- 14.4
Observational data: associations, not effects.
Further findings
Association of JIA with region of birth adjusted for genetic factors (MoBa subsample)
- No longer significant when adjusting for genetic factors
- MoBa: 238 patients with JIA, 57,392 controls
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Incidence and Genetic Risk of Juvenile Idiopathic Arthritis in Norway by Latitude. Arthritis Rheumatol. Published 19 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →