Lifetime clinical presentation of Still's disease in the Afro-descendant population of the French West Indies
Authors' conclusion
There is a rationale for considering Still's disease as a single entity in our AD population, focusing on the cardinal symptoms, but particular attention should be paid to the non-cardinal symptoms depending on the age of onset.
Study context
- Population
- Afro-descendant population of the French West Indies with sJIA or Still's disease, January 2000–202257% adults
- Participants
- 58 participants
- Exposure
- Children vs adults
- Outcome
- Similarity in cardinal and non-cardinal symptoms
Main finding
As reported in the abstract
Cardinal and non-cardinal symptoms
- Children vs Adults
- Typical skin rashes 100% vs 29.4%; P < 0.001
- Children vs Adults
- Coronary artery dilation 16% vs 0%; P = 0.03
- Children vs Adults
- Macrophage activation syndrome 52% vs 9%; P < 0.001
- Adults vs Children
- Inflammatory polyarthralgia without arthritis 91% vs 32%; P < 0.001
- Adults vs Children
- Pulmonary involvement 51.5% vs 4%; P < 0.001
- Diagnostic criteria overlapped in most cases, regardless of age
- 80%
Observational data: associations, not effects.
Further findings
Female sex
P = 0.03
Phenotypes
- Systemic
- 86%
- Systemic monophasic
- 43%
- Systemic polycyclic
- 43%
- Chronic polyarticular
- 14%
Number of relapses, use of biologics and mortality
- No difference found
Original publication
Lifetime clinical presentation of Still's disease in the Afro-descendant population of the French West Indies. Joint Bone Spine. Published 17 November 2024. doi:10.
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