Minor salivary gland biopsy in the diagnosis of definite ocular sarcoidosis in paediatric granulomatous uveitis
Authors' conclusion
MSGB is useful to improve the diagnosis of OS and to reduce the incidence of uveitis considered idiopathic in PGU.
Study context
- Population
- Children with non-infectious paediatric granulomatous uveitis (PGU) diagnosed between 2018 and 2023
- Participants
- 26 consecutive children
- Comparison
- Minor salivary gland biopsy (MSGB)+ vs MSGB-
- MSGB+n = 12
- Outcome
- Utility of MSGB in the diagnosis of definite ocular sarcoidosis in PGU
Methodological detailsconsecutive children, systematically performed MSGB within 3 months of diagnosis
- Consecutive children
- Systematically performed MSGB within 3 months of diagnosis
Performance
As reported in the abstract
Diagnosis of definite ocular sarcoidosis
| Test or model | Value | Sensitivity | NPV |
|---|---|---|---|
| MSGB+ | 46% | 92% | 93% |
MSGB+
Value46%
Sensitivity92%
NPV93%
- Definite ocular sarcoidosis (OS) diagnosed
- 13 of the 26 (50%)
- Idiopathic uveitis
- 8 (31%)
Further findings
| Outcome | P value |
|---|---|
| Characteristics MSGB+ vs MSGB-MSGB+ vs MSGB- | P = 0.02 |
| Characteristics MSGB+ vs MSGB-MSGB+ vs MSGB- | P = 0.003 |
| Characteristics MSGB+ vs MSGB-MSGB+ vs MSGB- | P = 0.005 |
| Characteristics MSGB+ vs MSGB-MSGB+ vs MSGB- | P = 0.03 |
Most frequent extra-ocular organ involvement at OS diagnosis
- Renal
- 46%
- Thoracic
- 46%
Treatment · median follow-up 3.1 (0.6-6.3) years
- First-line systemic corticosteroids
- 88%
- Needed MTX and/or anti-TNF-alpha to achieve inactive uveitis
- 88%
Original publication
Minor salivary gland biopsy in the diagnosis of definite ocular sarcoidosis in paediatric granulomatous uveitis. Pediatr Rheumatol Online J. Published 10 March 2025. doi:10.
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