Creatine and Coenzyme Q10 (CoQ10) with physical activity on muscle function in children with myositis: a proof-of-concept trial
Authors' conclusion
Cr+CoQ10 supplementation combined with physical activity showed positive effects; however, these findings may be attributable to chance imbalances in baseline values. Alternatively, the lack of statistical significance in the sensitivity analyses may reflect a Type II error, as the study size was set for the more powerful primary analysis. Further research is necessary to fully understand the impact of Cr and CoQ10 supplementation in children with JIIM.
Study context
- Population
- Children aged 9–17 with juvenile idiopathic inflammatory myopathies (JIIM) from SickKids' JIIM clinic8 male/ 7 female
- Participants
- 15 children
- Comparison
- Creatine (Cr)+CoQ10 supplementation combined with physical activity (intervention periods) vs placebo periods
- Primary endpoint
- Muscle function, measured by the Wingate Test
Methodological detailsall participants participated in both the placebo and intervention periods
- All participants participated in both the placebo and intervention periods
Primary result
As reported in the abstract
Mean difference, peak power
95 Watts
P = 0.02
INTERVENTION PERIODS vs PLACEBO PERIODS
Mean difference, mean power
74 Watts
P = 0.02
INTERVENTION PERIODS vs PLACEBO PERIODS
Mean difference, minimum power
47 Watts
P = 0.01
INTERVENTION PERIODS vs PLACEBO PERIODS
Secondary outcomes
| Outcome | Mean difference (Watts) | P value |
|---|---|---|
| Vertical jump peak powerIncreased significantly in the intervention period · not replicated in the prespecified sensitivity analyses | 493 | P = 0.02 |
Original publication
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