Clinical characteristics and prognosis of interstitial lung disease in systemic juvenile idiopathic arthritis: a two-center retrospective observational cohort study
Authors' conclusion
Patients with SJIA-ILD exhibited heightened inflammation, increased hip joint and cervical spine involvement, and were more susceptible to developing lymphopenia and MAS, suggesting a relatively poor prognosis.
Study context
- Population
- Children newly diagnosed with sJIA, two centres in China, October 2010 to December 2021
- Participants
- 176 children
- Exposure
- Systemic juvenile idiopathic arthritis (SJIA) with interstitial lung disease (ILD) vs SJIA without ILD
- ILDn = 35
- Non-ILDn = 141reference
- Outcome
- Clinical inactive disease without GC within 6 to 12 months of treatment
- Follow-up
- 6 to 12 months
Methodological detailstwo-center
- Two-center
Main finding
As reported in the abstract
P = 0.006
Observational data: associations, not effects.
Further findings
| Outcome | ILD | P value |
|---|---|---|
| Cervical spine involvement | 28.6% | P = 0.031 |
| Hip involvement | 40.0% | P = 0.029 |
| Macrophage activation syndrome (MAS) | 40% | P = 0.047 |
- Lymphopenia · more prone in ILD
- P = 0.009
- Combination therapy required · more in ILD
- P = 0.006
- Disease relapse rates
- P > 0.05
- Deaths from respiratory failure (ILD, non-remission)
- 2 · events
Complete remission and non-remission in ILD · median follow-up 6.0 years (range 3.9-9.5)
- Complete remission
- 54.3%
- Non-remission
- 17.1%
Disease relapse rates
- No significant difference between the two groups
Original publication
Clinical characteristics and prognosis of interstitial lung disease in systemic juvenile idiopathic arthritis: a two-center retrospective observational cohort study. Pediatr Rheumatol Online J. Published 24 October 2024. doi:10.
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