Clinical characteristics of 1020 childhood-onset systemic lupus erythematosus: data from a health centre in China
Authors' conclusion
This study is a large single-centre study on cSLE from China and clarifies the clinical phenotype and autoantibody spectrum of cSLE. The clinical manifestations and autoantibody spectrum of cSLE are diverse, with regional and populational differences.
Study context
- Population
- Patients with childhood-onset SLE (≥4 ACR classification criteria) diagnosed at Beijing Children's hospital, July 2006–October 2020808 female, 212 male
- Participants
- 1,020 patients
- Outcome
- Clinical characteristics of cSLE
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Female to male ratio
- 3.8:1
- Mean age at diagnosis, years (range 1.0-17.2)
- 11.1
- Time from first symptoms to diagnosis, months, average (range 0.1-132)
- 6
- Over 12 months from first symptoms to diagnosis
- 12%
- Onset manifestation: rash
- 37.2%
- Onset manifestation: fever
- 33.4%
- Onset manifestation: nephropathy
- 14.2%
- Onset manifestation: arthritis
- 13.6%
- Clinical manifestation: rash
- 67.9%
- Clinical manifestation: fever
- 57.5%
- Haematological involvement
- 59.4%
- LN
- 46.0%
- Arthritis
- 33.2%
Observational data: associations, not effects.
Further findings
- cSLE was more active and associated with more inflammation than aSLE patients
Original publication
Clinical characteristics of 1020 childhood-onset systemic lupus erythematosus: data from a health centre in China. Clin Exp Rheumatol. Published 19 January 2022. doi:10.
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